Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | PI4KA | P42356 | 2/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851 | 0.79 | PDPK1 (0.66) | PDPK1GDACDK2DPP4PNP | |
| SCHEMBL356178 | 0.79 | DPP4 (0.61) | PDPK1GDAALDH1A1CDK2DPP4 | |
| SCHEMBL16146695 | 0.79 | PDPK1 (0.41) | PDPK1GDAALDH1A1CDK2DPP4 | |
| SCHEMBL29375265 | 0.79 | PDPK1 (0.66) | PDPK1GDACDK2DPP4PNP | |
| SCHEMBL11212991 | 0.79 | PDPK1 (0.41) | PDPK1GDAALDH1A1CDK2DPP4 | |
| SCHEMBL2350025 | 0.79 | GDA (0.41) | PDPK1GDAALDH1A1CDK2DPP4 | |
| SCHEMBL27823604 | 0.79 | XDH (0.56) | PDPK1GDACDK2DPP4XDH | |
| SCHEMBL1336875 | 0.79 | PDPK1 (0.66) | PDPK1GDACDK2DPP4MAP3K5 | |
| SCHEMBL7670286 | 0.75 | TNNI3K (0.46) | GDAALDH1A1DPP4PNPTNNI3K | |
| SCHEMBL9705707 | 0.75 | CDK2 (0.56) | PDPK1GDAALDH1A1CDK2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039614-B2 | 4' -C-substituted-2-haloadenosine derivative | YAMASA CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |
| US-7625877-B2 | 4′-c-substituted-2-haloadenosine derivative | YAMASA CORPORATION (JP) | 2009-12-01 | — | — | US | disclosed |
| US-20090234110-A1 | 4' -C-substituted-2-haloadenosine derivative | KOHGO SATORU | 2009-09-17 | — | — | US | disclosed |
| US-20080153774-A1 | Acquired Immune Deficiency Syndrome (AIDS); 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine; anti-HIV activity, particularly against a multi-drug-resistant HIV strain; less cytotoxicity, exhibit resistance to inactivation by adenosine deaminase | KOHGO SATORU | 2008-06-26 | — | — | US | disclosed |
| EP-1589026-B1 | 4'-C-Substituted-2-Haloadenosine derivative | YAMASA CORP (JP) | 2008-03-12 | — | — | EP | disclosed |
| US-7339053-B2 | 4′-C-substituted-2-haloadenosine derivative | YAMASA CORPORATION (JP) | 2008-03-04 | — | — | US | disclosed |
| EP-1589026-A1 | 4'-C-Substituted-2-Haloadenosine derivative | YAMASA CORPORATION (JP) | 2005-10-26 | — | — | EP | disclosed |
| US-20050215512-A1 | 4' -C-substituted-2-haloadenosine derivative | YAMASA CORPORATION (JP) | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153774-A1 | Acquired Immune Deficiency Syndrome (AIDS); 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine; anti-HIV activity, particularly against a multi-drug-resistant HIV strain; less cytotoxicity, exhibit resistance to inactivation by adenosine deaminase | ADA, PNP, DCTD | PDPK1 1701/4885GDA 18/4885ALDH1A1 910/4885 |
| US-20050215512-A1 | 4' -C-substituted-2-haloadenosine derivative | ADORA1, ADORA2A, ADORA3 | PDPK1 2422/4885GDA 252/4885ALDH1A1 1567/4885 |
| US-20090234110-A1 | 4' -C-substituted-2-haloadenosine derivative | ADORA1, ADORA2A, ADORA3 | PDPK1 981/4885GDA 122/4885ALDH1A1 3694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.