Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 7/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.39 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.39 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705410 | 0.88 | SYK (0.46) | SYKCTSKCTSS | |
| SCHEMBL16798314 | 0.83 | SYK (0.48) | SYKCTSKCTSS | |
| SCHEMBL7312664 | 0.82 | MEN1 (0.50) | CYP3A4CYP2D6CYP2C19SYKALDH1A1 | |
| SCHEMBL28499841 | 0.81 | CTSK (0.48) | CYP3A4CYP2D6CYP2C19ALDH1A1CTSK | |
| SCHEMBL7305117 | 0.81 | F2 (0.47) | CYP3A4CYP2D6CYP2C19ALDH1A1CTSK | |
| SCHEMBL7422767 | 0.79 | SYK (0.47) | SYKCTSKCTSS | |
| SCHEMBL4583612 | 0.79 | MAPT (0.54) | SYKCTSKCTSS | |
| SCHEMBL16680112 | 0.79 | MAPT (0.54) | SYKCTSKCTSS | |
| SCHEMBL28008276 | 0.79 | CYP3A4 (0.52) | CYP3A4CYP2D6CYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL24876970 | 0.78 | CTSK (0.47) | CYP3A4CYP2D6CYP2C19ALDH1A1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220865-B1 | LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HYPOTENSIVE AGENTS | SANKYO COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4734410-A | Lactam derivatives and their use as hypotensive agents | SANKYO COMPANY LIMITED (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0220865-A2 | Lactam derivatives, their preparation and their use as hypotensive agents | SANKYO COMPANY LIMITED (JP) | 1987-05-06 | — | — | EP | disclosed |