Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 6/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16798314 | 0.92 | SYK (0.48) | SYKCTSKCTSSMEN1GAA | |
| SCHEMBL9705884 | 0.88 | CYP3A4 (0.47) | SYKCTSKCTSS | |
| SCHEMBL7422767 | 0.85 | SYK (0.47) | SYKCTSKCTSSMEN1GAA | |
| SCHEMBL16680112 | 0.85 | MAPT (0.54) | SYKCTSKCTSSGAAKMT2A | |
| SCHEMBL4583612 | 0.85 | MAPT (0.54) | SYKCTSKCTSSGAAKMT2A | |
| SCHEMBL5742834 | 0.83 | CTSK (0.50) | SYKCTSKCTSSMEN1GAA | |
| SCHEMBL6592966 | 0.82 | CTSK (0.49) | SYKCTSKCTSSMTNR1AMTNR1B | |
| SCHEMBL1429047 | 0.82 | CTSK (0.49) | SYKCTSKCTSSMTNR1AMTNR1B | |
| SCHEMBL16897058 | 0.82 | CTSK (0.49) | SYKCTSKCTSSMTNR1AMTNR1B | |
| SCHEMBL7146701 | 0.81 | MEN1 (0.56) | CTSKCTSSMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220865-B1 | LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HYPOTENSIVE AGENTS | SANKYO COMPANY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4734410-A | Lactam derivatives and their use as hypotensive agents | SANKYO COMPANY LIMITED (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0220865-A2 | Lactam derivatives, their preparation and their use as hypotensive agents | SANKYO COMPANY LIMITED (JP) | 1987-05-06 | — | — | EP | disclosed |