Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705660 | 0.85 | HTR3A (0.34) | HTR3AHTR2ASLC6A4HRH1PDE4D | |
| SCHEMBL9705630 | 0.85 | HTR3A (0.34) | HTR3AHTR2ASLC6A4HRH1PDE4D | |
| SCHEMBL9705653 | 0.85 | HTR3A (0.34) | HTR3AHTR2ASLC6A4HRH1PDE4D | |
| SCHEMBL8318695 | 0.78 | HTR3A (0.34) | HTR3ASMYD3 | |
| SCHEMBL8318685 | 0.78 | HTR3A (0.34) | HTR3ASMYD3 | |
| SCHEMBL8318689 | 0.78 | HTR3A (0.34) | HTR3ASMYD3 | |
| SCHEMBL7311217 | 0.71 | KDM4E (0.39) | SLC6A4KMT2AALDH1A1 | |
| SCHEMBL7318335 | 0.71 | KDM4E (0.39) | SLC6A4KMT2AALDH1A1 | |
| SCHEMBL7317477 | 0.71 | KDM4E (0.39) | SLC6A4KMT2AALDH1A1 | |
| SCHEMBL7395820 | 0.71 | HTR3A (0.59) | HTR3AHTR2ASLC6A4HRH1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518767-A2 | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-16 | — | — | EP | disclosed |