Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318689 | 1.00 | HTR3A (0.34) | HTR3ACNR1CNR2SMN1; SMN2HPGD | |
| SCHEMBL8318695 | 1.00 | HTR3A (0.34) | HTR3ACNR1CNR2SMN1; SMN2HPGD | |
| SCHEMBL9705653 | 0.83 | HTR3A (0.34) | HTR3A | |
| SCHEMBL9705660 | 0.83 | HTR3A (0.34) | HTR3A | |
| SCHEMBL9705630 | 0.83 | HTR3A (0.34) | HTR3A | |
| SCHEMBL9706213 | 0.78 | HTR3A (0.33) | HTR3ASMYD3 | |
| SCHEMBL9678634 | 0.74 | PTGS1 (0.38) | HTR3A | |
| SCHEMBL9678627 | 0.74 | PTGS1 (0.38) | HTR3A | |
| SCHEMBL8323720 | 0.74 | MEN1 (0.32) | — | |
| SCHEMBL7629711 | 0.74 | FFAR4 (0.39) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518767-A2 | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-16 | — | — | EP | claimed |
| US-5955470-A | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS, INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0518767-A2 | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-16 | — | — | EP | disclosed |