Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | QPCT | Q16769 | 2/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SOD1 | P00441 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9706477 | 0.90 | MEN1 (0.58) | KMT2AMEN1QPCTEGFRALDH1A1 | |
| SCHEMBL20659412 | 0.84 | CYP11B1 (0.53) | KMT2AMEN1QPCTCYP11B1CYP11B2 | |
| SCHEMBL13164564 | 0.78 | CYP1A2 (0.56) | KMT2AMEN1QPCTCYP11B1CYP11B2 | |
| SCHEMBL9662466 | 0.76 | KMT2A (0.49) | KMT2AMEN1QPCTCYP11B1CYP11B2 | |
| SCHEMBL18457438 | 0.76 | QPCT (0.56) | QPCTCYP11B1CYP11B2POLBSOD1 | |
| SCHEMBL15933383 | 0.74 | POLB (0.45) | KMT2AMEN1QPCTLMNATSHR | |
| SCHEMBL9706486 | 0.74 | MEN1 (0.56) | KMT2AMEN1ALDH1A1LMNAHPGD | |
| Bromide SCHEMBL9706367 | 0.73 | MEN1 (0.55) | KMT2AMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL9323999 | 0.72 | CYP11B1 (0.58) | KMT2AMEN1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL30674929 | 0.72 | CYP11B1 (0.58) | KMT2AMEN1CYP11B1CYP11B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198325-B1 | SUBSTITUTED ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-07-15 | — | — | EP | disclosed |
| US-4891429-A | CHEMICAL INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1990-01-02 | — | — | US | disclosed |
| US-4696930-A | CARDIOVASCULAR DISORDERS, ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1987-09-29 | — | — | US | disclosed |
| EP-0198325-A2 | Substituted aniline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-10-22 | — | — | EP | disclosed |