Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | QPCT | Q16769 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SOD1 | P00441 | 2/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9706487 | 0.90 | KMT2A (0.55) | MEN1KMT2AQPCTLMNAALDH1A1 | |
| SCHEMBL20659412 | 0.80 | CYP11B1 (0.53) | MEN1KMT2AQPCTLMNAALDH1A1 | |
| SCHEMBL9706486 | 0.76 | MEN1 (0.56) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL5838710 | 0.76 | MAPT (0.44) | MEN1KMT2ALMNAALDH1A1TSHR | |
| Bromide SCHEMBL9706367 | 0.75 | MEN1 (0.55) | MEN1KMT2ALMNAALDH1A1TSHR | |
| SCHEMBL5551707 | 0.74 | SOD1 (0.53) | MEN1KMT2AQPCTALDH1A1SMN1; SMN2 | |
| SCHEMBL9849578 | 0.74 | ALDH1A1 (0.61) | MEN1KMT2AQPCTLMNAALDH1A1 | |
| SCHEMBL9849642 | 0.74 | ALDH1A1 (0.61) | MEN1KMT2AQPCTLMNAALDH1A1 | |
| SCHEMBL5839061 | 0.74 | CHRM2 (0.44) | MEN1KMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL10771358 | 0.73 | TBXAS1 (0.67) | QPCTHSD17B10TBXAS1PRKCICYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198325-B1 | SUBSTITUTED ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-07-15 | — | — | EP | disclosed |
| US-4891429-A | CHEMICAL INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1990-01-02 | — | — | US | disclosed |
| US-4696930-A | CARDIOVASCULAR DISORDERS, ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1987-09-29 | — | — | US | disclosed |
| EP-0198325-A2 | Substituted aniline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-10-22 | — | — | EP | disclosed |