Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9468234 | 0.98 | HCAR2 (0.41) | HCAR2NPC1GABRPGABRDGABRA1 | |
| SCHEMBL27727527 | 0.88 | KDM4E (0.34) | HCAR2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9468230 | 0.85 | HCAR2 (0.33) | HCAR2KDM4E | |
| SCHEMBL5411887 | 0.78 | SMN1; SMN2 (0.49) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL27898717 | 0.77 | SMN1; SMN2 (0.47) | HCAR2NPC1MAPTKDM4EALDH1A1 | |
| SCHEMBL1326752 | 0.76 | KDM4E (0.51) | NPC1MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL27727536 | 0.73 | RAB9A (0.36) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL27766879 | 0.70 | KDM4E (0.37) | NPC1MAPTKDM4EALDH1A1ALOX15 | |
| SCHEMBL6819929 | 0.69 | MAPT (0.39) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL19616038 | 0.69 | POLB (0.39) | NPC1MAPTKDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514217-A1 | Antihypertensive benzofuran derivatives carrying 4-pyrazolylmethyl substituents | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |