Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27898717 | 0.86 | SMN1; SMN2 (0.47) | MAPTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL6820020 | 0.85 | NPC1 (0.44) | MAPTNPC1RAB9AGABRPGABRD | |
| SCHEMBL19616038 | 0.85 | POLB (0.39) | MAPTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL27533617 | 0.84 | LMNA (0.35) | MAPTPOLBL3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL29291196 | 0.80 | POLB (0.35) | MAPTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL10427543 | 0.80 | KMT2A (0.41) | MAPTL3MBTL1TDP1NPC1SMN1; SMN2 | |
| SCHEMBL24553584 | 0.78 | L3MBTL1 (0.39) | MAPTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL15825839 | 0.78 | GAA (0.43) | MAPTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL4768937 | 0.78 | RAB9A (0.47) | MAPTPOLBL3MBTL1TDP1NPC1 | |
| SCHEMBL29732371 | 0.78 | POLB (0.39) | MAPTPOLBL3MBTL1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100415738-C | Pyrazole contained diheterocyclic compound, its preparation and use | UNIV ZHEJIANG TECHNOLOGY (CN) | 2008-09-03 | — | — | CN | disclosed |
| CN-1300138-C | Diheterocyclic compound, its preparing method and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2007-02-14 | — | — | CN | disclosed |
| CN-1288149-C | Double heterocyclic compound containing pyrazole and pyrazole ketone, preparing method and its use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2006-12-06 | — | — | CN | disclosed |
| CN-1648125-A | Heterocyclic compound containing double pyrazole, preparing method and its use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-08-03 | — | — | CN | disclosed |
| CN-1648123-A | Double heterocyclic compound containing pyrazole and benzimidazole, preparing method and its use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-08-03 | — | — | CN | disclosed |
| CN-1648124-A | Double heterocyclic compound containing pyrazole and pyrazole ketone, preparing method and its use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-08-03 | — | — | CN | disclosed |
| CN-1644582-A | Pyrazole contained diheterocyclic compound, its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-07-27 | — | — | CN | disclosed |
| CN-1640875-A | Diheterocyclic compound, its preparing method and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-07-20 | — | — | CN | disclosed |
| WO-2004073610-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2004-09-02 | — | — | WO | disclosed |