Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.65 |
| ▸ | DRD3 | P35462 | 3/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.65 |
| ▸ | DRD1 | P21728 | 2/20 | 0.65 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.65 |
| ▸ | BCL2 | P10415 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369366 | 0.94 | GPX4 (0.60) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| SCHEMBL7081283 | 0.90 | CHRM2 (0.58) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| SCHEMBL7668121 | 0.87 | CHRM2 (0.83) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| Chlorcyclizine SCHEMBL13724147 | 0.79 | KCNH2 (1.00) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| SCHEMBL7267500 | 0.79 | CHRM2 (0.71) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| SCHEMBL16769329 | 0.79 | KCNH2 (0.76) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| SCHEMBL11212785 | 0.79 | KCNH2 (0.71) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| SCHEMBL13900811 | 0.79 | KCNH2 (0.76) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| Chlorcyclizine SCHEMBL4383 | 0.79 | KCNH2 (1.00) | KCNH2CHRM2ADRA2AADRA1ADRD3 | |
| Chlorcyclizine SCHEMBL12157065 | 0.79 | KCNH2 (1.00) | KCNH2CHRM2ADRA2AADRA1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0195374-B1 | N-SUBSTITUTED 3,4-DIHYDROPYRIMIDINE DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND COMPOSITION CONTAINING SAME FOR TREATING DISORDERS OF CARDIOVASCULAR SYSTEM | SUNTORY LIMITED (JP) | 1992-07-29 | — | — | EP | claimed |