Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorcyclizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 4/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 1.00 |
| ▸ | DRD3 | P35462 | 4/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 3/20 | 1.00 |
| ▸ | DRD1 | P21728 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 3/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | BCL2 | P10415 | 1/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorcyclizine SCHEMBL12157065 | 1.00 | KCNH2 (1.00) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| Chlorcyclizine SCHEMBL4383 | 1.00 | KCNH2 (1.00) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| Chlorcyclizine SCHEMBL16769331 | 1.00 | KCNH2 (1.00) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| Chlorcyclizine SCHEMBL321657 | 0.98 | CYP2D6 (1.00) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| Homochlorcyclizine SCHEMBL30402 | 0.94 | DRD3 (1.00) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| SCHEMBL2056217 | 0.93 | CHRM2 (0.86) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| Homochlorcyclizine SCHEMBL1977999 | 0.92 | SMN1; SMN2 (1.00) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| Homochlorcyclizine SCHEMBL122573 | 0.92 | SMN1; SMN2 (1.00) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| SCHEMBL7668121 | 0.91 | CHRM2 (0.83) | KCNH2CHRM2ADRA2ADRD3CHRM1 | |
| Cyclizine SCHEMBL4690 | 0.89 | CYP2D6 (1.00) | KCNH2CHRM2ADRA2ADRD3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |