Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | USP19 | O94966 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707080 | 0.79 | HPGD (0.39) | HSD17B10ALDH1A1HTTSMN1; SMN2HPGD | |
| SCHEMBL9707067 | 0.77 | KDM4E (0.42) | HSD17B10ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL9707085 | 0.77 | SMN1; SMN2 (0.68) | TSHRRECQLALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8696413 | 0.70 | HSD17B10 (0.77) | HSD17B10USP19TSHRHPGDMEN1 | |
| SCHEMBL9551146 | 0.70 | BACE1 (0.39) | HSD17B10ALDH1A1ADRB2SMN1; SMN2HPGD | |
| SCHEMBL9550715 | 0.69 | PTPN1 (0.41) | ALDH1A1SMN1; SMN2MEN1CYP1A2CYP3A4 | |
| SCHEMBL27630775 | 0.69 | HSD17B10 (0.75) | HSD17B10TSHRALDH1A1HTTHPGD | |
| SCHEMBL26802538 | 0.69 | HSD17B10 (0.75) | HSD17B10TSHRALDH1A1HTTHPGD | |
| SCHEMBL9510615 | 0.69 | SMN1; SMN2 (0.53) | TSHRALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL9814008 | 0.69 | SMN1; SMN2 (0.70) | HSD17B10ALDH1A1HTTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190685-B1 | HETEROCYCLIC AMIDES | G.D. Searle & Co. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-4981853-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0190685-A2 | Heterocyclic amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |