Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707067 | 0.82 | KDM4E (0.42) | HPGDKMT2AHSD17B10MEN1MAPT | |
| SCHEMBL9707047 | 0.79 | HSD17B10 (0.42) | HPGDKMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9707178 | 0.73 | RAB9A (0.63) | HPGDKMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6565612 | 0.66 | HPGD (0.53) | HPGDKMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9550786 | 0.65 | HSD17B10 (0.36) | SMN1; SMN2HSD17B10CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9550713 | 0.65 | THRB (0.37) | HPGDSMN1; SMN2HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL9512386 | 0.65 | SMN1; SMN2 (0.49) | HPGDKMT2ARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10017777 | 0.63 | EPHX2 (0.56) | GAACYP3A4CYP2C19 | |
| SCHEMBL8485613 | 0.63 | MMP1 (0.41) | HPGDGAAHSD17B10CYP3A4CYP2C19 | |
| SCHEMBL18909852 | 0.63 | EPHX2 (0.56) | GAACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190685-B1 | HETEROCYCLIC AMIDES | G.D. Searle & Co. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-4981853-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0190685-A2 | Heterocyclic amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |