Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.68 |
| ▸ | RAB9A | P51151 | 8/20 | 0.68 |
| ▸ | NPC1 | O15118 | 8/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9510615 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL9814008 | 0.89 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9513854 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL9510247 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9513665 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL9528422 | 0.81 | SMN1; SMN2 (0.97) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL9550710 | 0.81 | ALDH1A1 (0.49) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9707052 | 0.80 | ACE (0.46) | SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9813051 | 0.78 | PTPN1 (0.44) | SMN1; SMN2RAB9ANPC1ALDH1A1CYP1A2 | |
| SCHEMBL9814016 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190685-B1 | HETEROCYCLIC AMIDES | G.D. Searle & Co. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-4981853-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0190685-A2 | Heterocyclic amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |