SCHEMBL9707224

SCHEMBL9707224

CC(C)(C)[SiH2]OC(c1ccccc1)(c1ccccc1)[C@H]1CC(=O)[C@@H]1C(O[SiH2]C(C)(C)C)(c1ccccc1)c1ccccc1

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.31
KCNN4 O15554 1/20 0.30
CYP2C19 P33261 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9309557 0.86
SCHEMBL599563 0.84 MAPK1 (0.30) MAPK1
SCHEMBL600028 0.79 MAPK1 (0.32) MAPK1KCNN4CYP2C19HIF1A
SCHEMBL14321102 0.77 CYP3A4 (0.35) MAPK1
SCHEMBL15209217 0.72
SCHEMBL20447644 0.71 ALDH1A1 (0.36) MAPK1KCNN4
SCHEMBL15520559 0.70 CRBN (0.34) MAPK1CYP2C19
SCHEMBL15209428 0.70 LMNA (0.36)
SCHEMBL15209527 0.70 CHRM3 (0.30)
SCHEMBL354893 0.69 CHRM3 (0.34) KCNN4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0468352-A2 Novel nucleic acid derivatives Nippon Kayaku Kabushiki Kaisha (JP) 1992-01-29 EP disclosed