SCHEMBL9707327

SCHEMBL9707327

CC(=O)N(O)C(C)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.56
PTGS2 P35354 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9211809 0.89 ALOX5 (0.69) ALOX5
SCHEMBL9475050 0.84 ALOX5 (0.80) ALOX5PTGS2
SCHEMBL9376877 0.81 ALOX5 (0.51) ALOX5
SCHEMBL9376883 0.81 ALOX5 (0.51) ALOX5
SCHEMBL9474495 0.81 ALOX5 (0.51) ALOX5
SCHEMBL9195413 0.81 FFAR1 (0.54) ALOX5
SCHEMBL9707390 0.81 ALOX5 (0.51) ALOX5PTGS2
SCHEMBL9641680 0.78 ALOX5 (0.77) ALOX5
SCHEMBL9641600 0.77 ALOX5 (0.75) ALOX5
Ammonia Solution, Strong SCHEMBL9641537 0.77 ALOX5 (0.75) ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0196184-B1 ARYL DERIVATIVES THE WELLCOME FOUNDATION LIMITED (GB) 1992-09-16 EP disclosed
US-5036157-A Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents BURROUGHS WELLCOME CO. 1991-07-30 US disclosed
US-4977188-A Hydroamic acid derivatives BURROUGHS WELLCOME CO. (US) 1990-12-11 US disclosed
WO-1990001929-A1 NEW MEDICAL USE THE WELLCOME FOUNDATION LIMITED (GB) 1990-03-08 WO disclosed
US-4738986-A CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS BURROUGHS WELLCOME CO. (US) 1988-04-19 US disclosed
EP-0196184-A2 Aryl derivatives THE WELLCOME FOUNDATION LIMITED (GB) 1986-10-01 EP disclosed