Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22367061 | 0.80 | GAA (0.82) | GAAKDM4EALDH1A1GLAHTT | |
| SCHEMBL29349876 | 0.80 | GAA (0.82) | GAAKDM4EALDH1A1GLAHTT | |
| SCHEMBL13412901 | 0.80 | GAA (0.82) | GAAKDM4EALDH1A1GLAHTT | |
| SCHEMBL92077 | 0.80 | GAA (0.82) | GAAKDM4EALDH1A1GLAHTT | |
| SCHEMBL29633738 | 0.79 | PARP1 (0.56) | GAAKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2630573 | 0.79 | GAA (0.78) | GAAKDM4EALDH1A1GLAHTT | |
| SCHEMBL9709367 | 0.78 | NPC1 (0.54) | NPC1MTOR | |
| Acridone SCHEMBL29360611 | 0.76 | ALDH1A1 (1.00) | GAAKDM4EALDH1A1GLAHTT | |
| Acridone SCHEMBL29641306 | 0.76 | ALDH1A1 (1.00) | GAAKDM4EALDH1A1GLAHTT | |
| Acridone SCHEMBL11519726 | 0.76 | ALDH1A1 (1.00) | GAAKDM4EALDH1A1GLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471516-A1 | Tricyclic heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-19 | — | — | EP | disclosed |