Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 4/20 | 0.42 |
| ▸ | MMP8 | P22894 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709520 | 1.00 | MMP3 (0.42) | MMP3MMP8MMP9EPHX2TEAD3 | |
| SCHEMBL9709579 | 0.88 | FOLH1 (0.45) | MMP3MMP8MMP9EPHX2TEAD3 | |
| SCHEMBL9709585 | 0.88 | FOLH1 (0.45) | MMP3MMP8MMP9EPHX2TEAD3 | |
| SCHEMBL9709157 | 0.83 | TEAD3 (0.40) | MMP3MMP8MMP9EPHX2TEAD3 | |
| SCHEMBL12147930 | 0.81 | EPHX2 (0.53) | MMP3MMP8MMP9EPHX2KDM4E | |
| SCHEMBL9709766 | 0.81 | TEAD3 (0.44) | MMP3MMP8MMP9EPHX2TEAD3 | |
| SCHEMBL9709762 | 0.81 | TEAD3 (0.44) | MMP3MMP8MMP9EPHX2TEAD3 | |
| SCHEMBL19912663 | 0.80 | KDM4E (0.43) | MMP3MMP8MMP9MMP1KDM4E | |
| SCHEMBL9709674 | 0.80 | TEAD3 (0.41) | MMP3MMP8MMP9EPHX2TEAD3 | |
| SCHEMBL9709669 | 0.80 | TEAD3 (0.41) | MMP3MMP8MMP9EPHX2TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0493324-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1992-07-01 | — | — | EP | disclosed |