Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484073 | 0.90 | FFAR1 (0.53) | POLBCTDSP1FFAR1FFAR4PDPK1 | |
| Hydrochloric Acid SCHEMBL27881428 | 0.88 | FFAR1 (0.51) | POLBCTDSP1FFAR1FFAR4PDPK1 | |
| SCHEMBL29039047 | 0.86 | IAPP (0.58) | IAPPPOLBCTDSP1FFAR1FFAR4 | |
| SCHEMBL13286340 | 0.85 | TDP1 (0.59) | POLBFFAR1FFAR4 | |
| SCHEMBL9680739 | 0.84 | MMP12 (0.55) | POLBCTDSP1HDAC2HDAC8FFAR1 | |
| SCHEMBL12144575 | 0.82 | FFAR1 (0.59) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL9300862 | 0.82 | KMT2A (0.50) | IAPPPOLBCTDSP1 | |
| SCHEMBL1053043 | 0.82 | IAPP (0.66) | IAPPPOLBHDAC2HDAC8F2RL1 | |
| SCHEMBL1051720 | 0.82 | IAPP (0.61) | IAPPHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28238496 | 0.81 | IAPP (0.58) | IAPPPOLBCTDSP1F2RL1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157040-A | Treatment of hypertension, ocular hypertension and some CNS disorders | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0507594-A1 | Substituted quinolines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-10-07 | — | — | EP | disclosed |