Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1132385 | 0.79 | ALDH1A1 (0.39) | CYP19A1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3142532 | 0.73 | CYP11B2 (0.68) | CYP11B2CYP11B1CYP19A1ALDH1A1G6PC1 | |
| SCHEMBL31668803 | 0.73 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP19A1ALDH1A1KMT2A | |
| SCHEMBL9268248 | 0.73 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP19A1ALDH1A1KMT2A | |
| SCHEMBL5496395 | 0.73 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP19A1ALDH1A1KMT2A | |
| SCHEMBL15242510 | 0.70 | ALDH1A1 (0.58) | CYP11B2CYP11B1ALDH1A1G6PC1KMT2A | |
| Benzaldehyde SCHEMBL6051056 | 0.69 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1MAPK1CYP2A6 | |
| Styrene SCHEMBL10710522 | 0.69 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP19A1ALDH1A1G6PC1 | |
| SCHEMBL29691623 | 0.69 | CYP11B1 (0.86) | CYP11B2CYP11B1ALDH1A1KMT2ANPC1 | |
| SCHEMBL29691639 | 0.69 | CYP11B1 (0.86) | CYP11B2CYP11B1ALDH1A1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176314-B2 | IkB kinases (IKK) enzyme inhibitors, a imidazole-5-yl-quinoline derivatives compounds | AMGEN, INC. (US) | 2007-02-13 | — | — | US | disclosed |
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0493324-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1992-07-01 | — | — | EP | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |