Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 16/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732879 | 0.90 | HRH1 (0.51) | TBXAS1HRH1CYP2A6CYP3A4 | |
| SCHEMBL9732224 | 0.87 | HRH1 (0.56) | TBXAS1HRH1CYP2A6CYP3A4 | |
| SCHEMBL9734346 | 0.86 | HRH1 (0.49) | TBXAS1HRH1CYP2A6TBXA2RCYP3A4 | |
| SCHEMBL9732269 | 0.84 | TBXAS1 (0.60) | TBXAS1HRH1CYP2A6TBXA2R | |
| SCHEMBL9732813 | 0.83 | HRH1 (0.48) | TBXAS1HRH1CYP2A6CYP3A4 | |
| SCHEMBL10622938 | 0.81 | TBXAS1 (0.57) | TBXAS1CYP2A6 | |
| SCHEMBL9732456 | 0.80 | TBXAS1 (0.47) | TBXAS1 | |
| SCHEMBL5962751 | 0.80 | TBXAS1 (0.64) | TBXAS1HRH1 | |
| SCHEMBL30178297 | 0.80 | TBXAS1 (0.64) | TBXAS1HRH1 | |
| SCHEMBL9710028 | 0.79 | TBXAS1 (0.78) | TBXAS1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0493324-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1992-07-01 | — | — | EP | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |