Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9710094 | 0.89 | PRKAA2 (0.38) | DHODH | |
| SCHEMBL9709653 | 0.86 | DHODH (0.41) | DHODH | |
| SCHEMBL9709521 | 0.85 | PDE4A (0.43) | — | |
| SCHEMBL9709610 | 0.84 | — | — | |
| SCHEMBL9709742 | 0.83 | — | — | |
| SCHEMBL9710152 | 0.78 | AGTR1 (0.38) | DHODHAGTR1 | |
| SCHEMBL9709598 | 0.78 | PLA2G2A (0.43) | — | |
| SCHEMBL9709489 | 0.75 | PDE4A (0.45) | — | |
| SCHEMBL9040776 | 0.74 | — | — | |
| SCHEMBL9709728 | 0.74 | PDE4A (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157040-A | Treatment of hypertension, ocular hypertension and some CNS disorders | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0507594-A1 | Substituted quinolines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1992-10-07 | — | — | EP | disclosed |