SCHEMBL9709798

SCHEMBL9709798

COC=C(C(=O)O)c1ccccc1C=Cc1csc(-c2ccc(Cl)cc2Cl)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKD3 O94806 1/20 0.40
PRKCG P05129 1/20 0.40
PRKCB P05771 1/20 0.40
IL1R1 P14778 1/20 0.40
PRKCA P17252 1/20 0.40
TNFRSF1A P19438 1/20 0.40
PRKCH P24723 1/20 0.40
PRKCI P41743 1/20 0.40
PRKCE Q02156 1/20 0.40
PRKCQ Q04759 1/20 0.40
PRKCZ Q05513 1/20 0.40
PRKCD Q05655 1/20 0.40
PRKD1 Q15139 1/20 0.40
TLR7 Q9NYK1 1/20 0.40
SHMT1 P34896 7/20 0.39
SHMT2 P34897 5/20 0.39
KDM4E B2RXH2 3/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
CRHBP P24387 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9566808 0.83 PRKD3 (0.46) PRKD3PRKCGPRKCBIL1R1PRKCA
SCHEMBL9566809 0.83 PRKD3 (0.46) PRKD3PRKCGPRKCBIL1R1PRKCA
SCHEMBL7138622 0.82 MAPT (0.38) TLR7KDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL7138626 0.82 MAPT (0.38) TLR7KDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL10431303 0.77 TLR7 (0.34) TLR7KDM4ENPC1RAB9AMAPT
SCHEMBL9709774 0.76 SHMT1 (0.48) PRKD3PRKCGPRKCBIL1R1PRKCA
SCHEMBL10431305 0.75 SLC6A3 (0.34) KDM4ENPC1RAB9AMAPTMEN1
SCHEMBL9485740 0.74 KDM4E (0.33) KDM4ENPC1RAB9AMAPTMEN1
SCHEMBL9487695 0.72 DHODH (0.33) KDM4ENPC1RAB9ADHODHMAPT
SCHEMBL9487688 0.72 DHODH (0.33) KDM4ENPC1RAB9ADHODHMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0489660-A1 Utilization of thiazolylalkoxyacrylates for the preparation of insecticidal and/or acaricidal compositions ROUSSEL-UCLAF (FR) 1992-06-10 EP disclosed