SCHEMBL9711095

SCHEMBL9711095

NC(S)=Nc1cc(Cl)ccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.44
ITGB3 P05106 1/20 0.44
ITGAV P06756 1/20 0.44
ALDH1A1 P00352 2/20 0.42
TSHR P16473 2/20 0.40
TP53 P04637 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
CYP3A4 P08684 1/20 0.40
HSD17B10 Q99714 1/20 0.40
HTR3E A5X5Y0 5/20 0.39
HTR3B O95264 5/20 0.39
HTR3A P46098 5/20 0.39
HTR3D Q70Z44 5/20 0.39
HTR3C Q8WXA8 5/20 0.39
SLC22A2 O15244 2/20 0.38
SLC22A1 O15245 2/20 0.38
SLC22A3 O75751 2/20 0.38
PLAU P00749 2/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11883551 0.83 HTR3E (0.57) SIGMAR1ITGB3ITGAVALDH1A1TSHR
Hydrochloric Acid SCHEMBL3418772 0.80 SIGMAR1 (0.50) SIGMAR1ITGB3ITGAVALDH1A1TSHR
Nitric Acid SCHEMBL7813154 0.73 HTR3E (0.46) SIGMAR1ITGB3ITGAVALDH1A1TSHR
SCHEMBL15188822 0.70 CYP3A4 (0.46) SIGMAR1ITGB3ITGAVALDH1A1TSHR
SCHEMBL3584601 0.69 MAPT (0.38) SIGMAR1ITGB3ITGAVALDH1A1CYP3A4
SCHEMBL11709281 0.67 TP53 (0.48) SIGMAR1ITGB3ITGAVALDH1A1TSHR
SCHEMBL11349652 0.67 TP53 (0.48) ALDH1A1TSHRTP53TDP1CYP3A4
SCHEMBL11709272 0.67 TP53 (0.48) SIGMAR1ITGB3ITGAVALDH1A1TSHR
SCHEMBL30012086 0.67 TP53 (0.48) SIGMAR1ITGB3ITGAVALDH1A1TSHR
SCHEMBL1547579 0.67 TP53 (0.48) SIGMAR1ALDH1A1TSHRTP53TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0290886-B1 PROCESS FOR THE PREPARATION OF 2,5-DICHLOROPHENYLTHIOGLYCOLIC ACID CASSELLA Aktiengesellschaft (DE) 1992-01-08 EP claimed
US-4918221-A DIAZOTIZATION OF 2,5-DICHLOROANILINE, CATALYSIS, SALT FORMATION, HYDROLYSIS, AND CONDENSATION; AIR POLLUTION CONTROL; BY-PRODUCT INHIBITION CASSELLA AG (DE) 1990-04-17 US claimed
US-4918221-A DIAZOTIZATION OF 2,5-DICHLOROANILINE, CATALYSIS, SALT FORMATION, HYDROLYSIS, AND CONDENSATION; AIR POLLUTION CONTROL; BY-PRODUCT INHIBITION CASSELLA AG (DE) 1990-04-17 US disclosed
US-4918221-A DIAZOTIZATION OF 2,5-DICHLOROANILINE, CATALYSIS, SALT FORMATION, HYDROLYSIS, AND CONDENSATION; AIR POLLUTION CONTROL; BY-PRODUCT INHIBITION CASSELLA AG (DE) 1990-04-17 US disclosed
EP-0290886-A1 Process for the preparation of 2,5-dichlorophenylthioglycolic acid CASSELLA Aktiengesellschaft (DE) 1988-11-17 EP disclosed