Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581821 | 0.85 | TDP1 (0.64) | MEN1KMT2ATDP1MTNR1AMTNR1B | |
| SCHEMBL31332133 | 0.85 | TDP1 (0.64) | MEN1KMT2ATDP1MTNR1AMTNR1B | |
| SCHEMBL5236753 | 0.84 | MEN1 (0.47) | MEN1KMT2ATDP1MTNR1AMTNR1B | |
| SCHEMBL7235618 | 0.79 | TDP1 (0.69) | MEN1KMT2ATDP1MTNR1ACYP1A2 | |
| SCHEMBL9711171 | 0.79 | MEN1 (0.45) | MEN1KMT2ATDP1CYP2C19CYP1A2 | |
| SCHEMBL27366928 | 0.78 | MAPT (0.48) | MEN1KMT2ATDP1LMNAPKM | |
| SCHEMBL18015817 | 0.78 | CYP2A6 (0.43) | MEN1KMT2AMTNR1AMTNR1BCYP2C19 | |
| SCHEMBL3571906 | 0.78 | CYP2A6 (0.43) | MEN1KMT2ATDP1CYP2C19CYP1A2 | |
| SCHEMBL29792638 | 0.78 | CYP2A6 (0.43) | MEN1KMT2ATDP1CYP2C19CYP1A2 | |
| SCHEMBL15352213 | 0.78 | CYP2A6 (0.43) | MEN1KMT2AMTNR1AMTNR1BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0304190-B1 | (ARYLSULPHONYL)NITROMETHANES, PROCESS FOR THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-08 | — | — | EP | disclosed |
| EP-0304190-A1 | (Arylsulphonyl)nitromethanes, process for their preparation and use in pharmaceutical compositions | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-02-22 | — | — | EP | disclosed |