SCHEMBL9711376

SCHEMBL9711376

OCC(Cn1cncn1)c1ccc(Cl)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2C P18825 2/20 0.44
CYP19A1 P11511 1/20 0.43
LMNA P02545 1/20 0.43
PKM P14618 1/20 0.43
KMT2A Q03164 3/20 0.40
POLB P06746 2/20 0.40
MAPT P10636 2/20 0.39
CYP3A4 P08684 4/20 0.39
CYP1A2 P05177 3/20 0.39
ALDH1A1 P00352 2/20 0.39
GABRA1 P14867 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
KDM4E B2RXH2 1/20 0.39
HTT P42858 1/20 0.39
MEN1 O00255 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2C9 P11712 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29364531 1.00 ADRA2C (0.44) ADRA2CCYP19A1LMNAPKMKMT2A
SCHEMBL10978037 0.92 CYP19A1 (0.46) ADRA2CCYP19A1LMNAPKMKMT2A
SCHEMBL10364855 0.86 CYP19A1 (0.43) ADRA2CCYP19A1LMNAPKMKMT2A
Alcohol SCHEMBL27859648 0.84 CYP3A4 (0.39) ADRA2CCYP19A1LMNAPKMKMT2A
Penconazole SCHEMBL29416459 0.84 CYP19A1 (0.41) ADRA2CCYP19A1LMNAPKMKMT2A
SCHEMBL10833443 0.84 CYP19A1 (0.41) ADRA2CCYP19A1LMNAPKMKMT2A
Penconazole SCHEMBL24791 0.84 CYP19A1 (0.41) ADRA2CCYP19A1LMNAPKMKMT2A
SCHEMBL10832681 0.84 CYP3A4 (0.45) ADRA2CCYP19A1LMNAPKMKMT2A
Penconazole SCHEMBL3003031 0.84 CYP19A1 (0.41) ADRA2CCYP19A1LMNAPKMKMT2A
Penconazole SCHEMBL8050480 0.84 CYP19A1 (0.41) ADRA2CCYP19A1LMNAPKMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110612119-A Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents 西雅图儿童医院(DBA西雅图儿童研究所) 2019-12-24 CN claimed
EP-3230268-B1 PROCESS FOR THE PREPARATION OF TETRACONAZOLE ISAGRO SPA (IT) 2018-12-12 EP claimed
WO-2018148224-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) 2018-08-16 WO claimed
US-9884829-B2 Process for the preparation of tetraconazole ISAGRO S.P.A. (IT) 2018-02-06 US claimed
US-20170327473-A1 PROCESS FOR THE PREPARATION OF TETRACONAZOLE BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT 2017-11-16 US claimed
US-20240226160-A9 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2024-07-11 US disclosed
US-20240210288-A1 Representative Diagnostics VENTANA MED SYST INC (US) 2024-06-27 US disclosed
US-20240131072-A1 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2024-04-25 US disclosed
US-11959838-B2 Representative diagnostics VENTANA MEDICAL SYSTEMS, INC. (US) 2024-04-16 US disclosed
US-20230322925-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS SEATTLE CHILDREN’S HOSPITAL DBA SEATTLE CHILDREN’S RES INSTITUTE (US) 2023-10-12 US disclosed
US-20230172981-A1 METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST (US) 2023-06-08 US disclosed
US-11649288-B2 Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents SEATTLE CHILDREN'S HOSPITAL (US) 2023-05-16 US disclosed
EP-3230268-A1 PROCESS FOR THE PREPARATION OF TETRACONAZOLE ISAGRO S.p.A. (IT) 2017-10-18 EP disclosed
WO-2017079763-A1 REPRESENTATIVE DIAGNOSTICS VENTANA MEDICAL SYSTEMS, INC. (US) 2017-05-11 WO disclosed
WO-2016092573-A1 PROCESS FOR THE PREPARATION OF TETRACONAZOLE ISAGRO S.P.A. (IT) 2016-06-16 WO disclosed
WO-2016092573-A1 PROCESS FOR THE PREPARATION OF TETRACONAZOLE ISAGRO S.P.A. (IT) 2016-06-16 WO disclosed
WO-2016092573-A1 PROCESS FOR THE PREPARATION OF TETRACONAZOLE ISAGRO S.P.A. (IT) 2016-06-16 WO disclosed
US-5081141-A 1,2,4-triazole derivatives as fungicides MONTEDISON S.P.A. (IT) 1992-01-14 US disclosed
EP-0234242-B1 FUNGICIDAL AZOLYL-DERIVATIVES MONTEDIPE S.r.l. (IT) 1991-08-07 EP disclosed
EP-0234242-A2 Fungicidal azolyl-derivatives MONTEDIPE S.r.l. (IT) 1987-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11649288-B2 Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents PHOSPHO1, LCAT, CD47 ADRA2C 2576/4885CYP19A1 4556/4885LMNA 3363/4885
US-20170327473-A1 PROCESS FOR THE PREPARATION OF TETRACONAZOLE CYP51A1, CYP3A4, CYP3A43 ADRA2C 460/4885CYP19A1 389/4885LMNA 2520/4885
US-20230322925-A1 PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS PHOSPHO1, LCAT, CD47 ADRA2C 2576/4885CYP19A1 4556/4885LMNA 3363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.