Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.66 |
| ▸ | DRD1 | P21728 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10515430 | 0.85 | MAPT (0.67) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7289675 | 0.85 | ADRA1A (0.73) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7436653 | 0.85 | MAPT (0.73) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9381507 | 0.84 | ADRA1A (0.91) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10366027 | 0.84 | ABCB1 (0.73) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7343603 | 0.84 | MAPT (0.70) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10889767 | 0.84 | MAPT (0.71) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3436033 | 0.84 | MAPT (0.71) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL10743742 | 0.83 | ADRA1A (0.91) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11682220 | 0.83 | MAPT (0.70) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |