SCHEMBL9713362

SCHEMBL9713362

CCc1cnc(C#Cc2ccc(OC(F)(F)C(F)F)cc2)nc1

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ACACB O00763 12/20 0.39
MCHR1 Q99705 1/20 0.39
RXRA P19793 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2B Q13224 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.34
TRPV1 Q8NER1 1/20 0.32
CETP P11597 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9713673 0.90 MCHR1 (0.38) ACACBMCHR1CETP
SCHEMBL9713096 0.89 ACACB (0.45) ACACBMCHR1RXRAGRIN1GRIN2B
SCHEMBL9713143 0.88 MCHR1 (0.37) ACACBMCHR1L3MBTL1CETP
SCHEMBL9713931 0.87 MAPT (0.40) ACACBMCHR1L3MBTL1CETP
SCHEMBL9713150 0.86 L3MBTL1 (0.39) ACACBMCHR1L3MBTL1CETP
SCHEMBL9713550 0.86 L3MBTL1 (0.39) ACACBMCHR1L3MBTL1CETP
SCHEMBL9712902 0.86 L3MBTL1 (0.39) ACACBMCHR1L3MBTL1CETP
SCHEMBL9713632 0.85 MCHR1 (0.36) ACACBMCHR1RXRAGRIN1GRIN2B
SCHEMBL9713202 0.85 ACACB (0.46) ACACBMCHR1
SCHEMBL9712996 0.80 ACACB (0.43) ACACBMCHR1RXRAGRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5164114-A LIQUID CRYSTAL MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1992-11-17 US disclosed