SCHEMBL9713202

SCHEMBL9713202

CCc1ccc(C#Cc2ccc(OC(F)(F)C(F)F)cc2)nc1

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ACACB O00763 13/20 0.46
MCHR1 Q99705 3/20 0.39
FFAR1 O14842 1/20 0.37
FFAR4 Q5NUL3 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9713435 0.90 ACACB (0.49) ACACBMCHR1FFAR1FFAR4
SCHEMBL9713010 0.90 ACACB (0.49) ACACBMCHR1FFAR1FFAR4
SCHEMBL9713252 0.88 ACACB (0.47) ACACBMCHR1FFAR1FFAR4
SCHEMBL9713710 0.87 ACACB (0.47) ACACBMCHR1FFAR1FFAR4
SCHEMBL9713352 0.86 ACACB (0.46) ACACBMCHR1FFAR1FFAR4
SCHEMBL9712998 0.86 ACACB (0.46) ACACBMCHR1FFAR1FFAR4
SCHEMBL9713536 0.86 ACACB (0.46) ACACBMCHR1FFAR1FFAR4
SCHEMBL10515393 0.86 ACACB (0.46) ACACBMCHR1FFAR1FFAR4
SCHEMBL9713556 0.86 ACACB (0.52) ACACBMCHR1
SCHEMBL9713362 0.85 ACACB (0.39) ACACBMCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5164114-A LIQUID CRYSTAL MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1992-11-17 US disclosed
EP-0306521-B1 ETHINE DERIVATIVES AS COMPOUNDS OF LIQUID CRYSTAL PHASES MERCK PATENT GmbH (DE) 1991-10-16 EP disclosed
EP-0306521-A1 ETHINE DERIVATIVES AS COMPOUNDS OF LIQUID CRYSTAL PHASES. MERCK PATENT GMBH (DE) 1989-03-15 EP disclosed
WO-1988007516-A1 ETHINE DERIVATIVES AS COMPOUNDS OF LIQUID CRYSTAL PHASES MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1988-10-06 WO disclosed