Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10831586 | 0.88 | NPC1 (0.42) | NPC1LMNANFKB1NFKB2RELA | |
| SCHEMBL9713497 | 0.85 | PTGS2 (0.40) | LMNAPTGS2CYP3A4HTT | |
| SCHEMBL9628087 | 0.78 | HTT (0.56) | LMNAPTGS2CYP3A4CYP2C9CNR2 | |
| SCHEMBL9627400 | 0.78 | HTT (0.56) | LMNAPTGS2CYP3A4CYP2C9CNR2 | |
| SCHEMBL9713761 | 0.78 | MAPT (0.43) | NPC1LMNASMN1; SMN2HTT | |
| SCHEMBL9713791 | 0.78 | PTGS2 (0.45) | PTGS2HTT | |
| SCHEMBL9627747 | 0.77 | HTT (0.57) | LMNAPTGS2CYP3A4CYP2C9CNR2 | |
| SCHEMBL9713989 | 0.76 | BACE1 (0.40) | CYP3A4HTT | |
| SCHEMBL9660327 | 0.74 | HTT (0.50) | LMNAPTGS2CYP3A4CYP2C9CNR2 | |
| SCHEMBL9713395 | 0.74 | ABCB11 (0.52) | NPC1SMN1; SMN2PTGS2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |