Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628275 | 0.88 | HTT (0.48) | HTTPTPN1CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL9713982 | 0.85 | HTT (0.56) | HTTPTPN1POLBSMN1; SMN2BLM | |
| SCHEMBL9627873 | 0.83 | HTT (0.60) | HTTPTPN1PKMSMN1; SMN2MAPT | |
| SCHEMBL9627484 | 0.80 | HTT (0.51) | HTTPTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL9713348 | 0.77 | HTT (0.48) | HTTPTPN1CYP1A2ADRA2ACYP2D6 | |
| SCHEMBL9628040 | 0.76 | HTT (0.58) | HTTMAPTHSD17B10KDM4EGAA | |
| SCHEMBL9627747 | 0.75 | HTT (0.57) | HTTADRA2AOPRK1MAPTHSD17B10 | |
| SCHEMBL9713395 | 0.75 | ABCB11 (0.52) | HTTHTR2CPOLBSMN1; SMN2MAPT | |
| SCHEMBL9628087 | 0.74 | HTT (0.56) | HTTADRA2AOPRK1MAPTHSD17B10 | |
| SCHEMBL9627400 | 0.74 | HTT (0.56) | HTTADRA2AOPRK1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |