Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3902453 | 0.82 | KMT2A (0.73) | PAX8MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2957229 | 0.79 | KMT2A (0.54) | PAX8MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28775114 | 0.77 | SMN1; SMN2 (0.65) | PAX8MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL642700 | 0.75 | KMT2A (0.81) | MAPTKMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL16922176 | 0.75 | KMT2A (0.81) | MAPTKMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL2961835 | 0.74 | MAPT (0.52) | PAX8MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14415151 | 0.74 | SMN1; SMN2 (0.50) | MAPTKMT2AMEN1SMN1; SMN2HTT | |
| Phosphine SCHEMBL28320532 | 0.73 | KMT2A (0.78) | MAPTKMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL11769655 | 0.73 | MEN1 (0.50) | MAPTKMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL13408629 | 0.73 | SMN1; SMN2 (0.51) | PAX8MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084449-A | Bactericides and antiprotozoa agents | DR. KARL THOMAE GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4992430-A | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase | DR. KARL THOMAE GMBH (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4829058-A | INHIBITORS OF BACTERIA, MYCOBACTERIA AND PLASMODIA | DR. KARL THOMAE GMBH (DE) | 1989-05-09 | — | — | US | disclosed |