Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713991 | 0.85 | ALOX15 (0.41) | MAPTTP53TOP2AFPR1ALOX15 | |
| SCHEMBL9642136 | 0.84 | TP53 (0.49) | MAPTTP53KMT2AKDM4EMTNR1A | |
| SCHEMBL9627754 | 0.82 | TOP2A (0.48) | KMT2AKDM4EMEN1RECQLTOP2A | |
| SCHEMBL9713400 | 0.82 | TOP2A (0.47) | KMT2AMEN1TOP2AALOX15 | |
| SCHEMBL10704787 | 0.81 | TOP2A (0.46) | TOP2AALOX15 | |
| SCHEMBL9713270 | 0.81 | TOP2A (0.47) | KMT2AKDM4EMEN1RECQLTOP2A | |
| SCHEMBL9642492 | 0.80 | TP53 (0.46) | MAPTTP53KMT2AKDM4EMTNR1A | |
| SCHEMBL9643595 | 0.79 | MAPT (0.45) | MAPTTP53KDM4EMTNR1AMTNR1B | |
| SCHEMBL9643375 | 0.79 | MAPT (0.45) | MAPTTP53KDM4EMTNR1AMTNR1B | |
| SCHEMBL9627564 | 0.79 | ALOX15 (0.43) | MAPTKMT2AKDM4EMEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |