SCHEMBL9714174

SCHEMBL9714174

CC(C(=O)NNC=S)C(O)(Cn1cncn1)c1ccccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.37
KMT2A Q03164 3/20 0.37
MEN1 O00255 1/20 0.37
CYP3A4 P08684 9/20 0.36
CYP2C9 P11712 8/20 0.36
CYP2C19 P33261 8/20 0.36
CYP2B6 P20813 1/20 0.36
CYP3A5 P20815 1/20 0.36
CYP3A7 P24462 1/20 0.36
MAPK1 P28482 1/20 0.36
CYP3A43 Q9HB55 1/20 0.36
CYP46A1 Q9Y6A2 1/20 0.36
LMNA P02545 1/20 0.36
CYP1A2 P05177 6/20 0.35
CYP2D6 P10635 6/20 0.35
KCNH2 Q12809 2/20 0.35
ALDH1A1 P00352 1/20 0.34
AR P10275 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9714376 0.89 CYP3A4 (0.44) HSP90AA1KMT2AMEN1CYP3A4CYP2C9
SCHEMBL9714166 0.86 HSP90AA1 (0.41) HSP90AA1KMT2AMEN1CYP3A4CYP2C9
SCHEMBL9714177 0.82 MAPT (0.35) HSP90AA1KMT2AMEN1CYP3A4CYP2C9
SCHEMBL9713954 0.81 CYP3A4 (0.58) HSP90AA1CYP3A4CYP2C9CYP2C19CYP2B6
SCHEMBL9714258 0.80 HSP90AA1 (0.41) HSP90AA1KMT2AMEN1CYP3A4CYP2C9
SCHEMBL9862503 0.74 CYP3A4 (0.47) HSP90AA1KMT2AMEN1CYP3A4CYP2C9
SCHEMBL9004868 0.74 HSP90AA1 (0.44) HSP90AA1KMT2AMEN1CYP3A4CYP2C9
SCHEMBL9714235 0.74 CYP3A4 (0.48) HSP90AA1KMT2AMEN1CYP3A4CYP2C9
SCHEMBL9243135 0.73 HSP90AA1 (0.43) HSP90AA1KMT2AMEN1CYP3A4CYP2C9
SCHEMBL27308603 0.73 HSP90AA1 (0.52) HSP90AA1KMT2ACYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992017474-A1 TRIAZOLE ANTIFUNGAL AGENTS PFIZER LIMITED (GB) 1992-10-15 WO disclosed