Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 9/20 | 0.34 |
| ▸ | BCL2 | P10415 | 3/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9643142 | 0.84 | BCL2 (0.40) | NPC1LMNANFKB1NFKB2RELA | |
| SCHEMBL9713222 | 0.83 | PTPN1 (0.38) | NPC1LMNASMN1; SMN2PTPN1SOAT1 | |
| SCHEMBL9713336 | 0.76 | PTPN1 (0.40) | PTPN1SOAT1 | |
| SCHEMBL9713644 | 0.76 | PTPN1 (0.37) | PTPN1SOAT1 | |
| SCHEMBL9713998 | 0.76 | MAPT (0.40) | LMNASMN1; SMN2BCL2MCL1CYP2C9 | |
| SCHEMBL9713322 | 0.74 | PTPN1 (0.41) | NPC1PTPN1SOAT1 | |
| SCHEMBL9714225 | 0.74 | CYP3A4 (0.44) | NPC1LMNANFKB1NFKB2RELA | |
| SCHEMBL9713908 | 0.74 | CDC25B (0.56) | PTPN1SOAT1 | |
| SCHEMBL9628579 | 0.74 | CDC25B (0.56) | PTPN1SOAT1 | |
| SCHEMBL11247136 | 0.74 | CDC25B (0.56) | PTPN1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |