SCHEMBL9714787

SCHEMBL9714787

COc1ccc(CC=NO)c(C(C)C)c1OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 2/20 0.34
CYP2C19 P33261 1/20 0.34
ALDH1A1 P00352 2/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
KDM4E B2RXH2 4/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
ATM Q13315 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
POLB P06746 2/20 0.32
CYP1A2 P05177 1/20 0.32
CHRM2 P08172 1/20 0.32
SLC6A4 P31645 1/20 0.32
OPRD1 P41143 1/20 0.32
OPRK1 P41145 1/20 0.32
TSHR P16473 2/20 0.31
NFE2L2 Q16236 1/20 0.31
HPGD P15428 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9714815 0.80 KDM4E (0.37) AOC3CYP2C19ALDH1A1KDM4EMEN1
SCHEMBL7274049 0.74 AOC3 (0.36) AOC3CYP2C19MAPTKDM4EMEN1
Hydrochloric Acid SCHEMBL5138936 0.73 AOC3 (0.41) AOC3MEN1KMT2ASMN1; SMN2POLB
SCHEMBL15713200 0.71 SMN1; SMN2 (0.40) AOC3ALDH1A1MAPTKDM4ESMN1; SMN2
Hydrochloric Acid SCHEMBL7273717 0.71 TAAR1 (0.46) AOC3LMNAKDM4EMEN1KMT2A
SCHEMBL8459648 0.69 CYP2C19 (0.40) CYP2C19ALDH1A1MAPTKDM4EMEN1
SCHEMBL28971730 0.66 PTGS2 (0.52) AOC3ALDH1A1MAPTKDM4EPOLB
SCHEMBL7179592 0.65 TUBB1 (0.39) ALDH1A1LMNAMAPTKDM4ESMN1; SMN2
SCHEMBL29740115 0.65 TUBB1 (0.39) ALDH1A1LMNAMAPTKDM4ESMN1; SMN2
SCHEMBL7363779 0.65 ALDH1A1 (0.61) ALDH1A1LMNAMAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0285890-B1 NEW PROCESS FOR THE SYNTHESIS OF THE ALPHA-(1-METHYLETHYL)-3,4-DIMETHOXYBENZENE-ACETONITRILE ALFA WASSERMANN SPA (IT) 1992-11-19 EP claimed