Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714881 | 1.00 | POLB (0.41) | POLBTRPA1GAACES2CES1 | |
| SCHEMBL9774843 | 0.84 | TSHR (0.41) | TSHRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9774831 | 0.84 | TSHR (0.41) | TSHRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9774839 | 0.84 | TSHR (0.41) | TSHRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9714880 | 0.84 | GSK3B (0.41) | POLBTRPA1GAACES2CES1 | |
| SCHEMBL9714877 | 0.84 | GSK3B (0.41) | POLBTRPA1GAACES2CES1 | |
| SCHEMBL9714886 | 0.82 | GSK3B (0.42) | POLBTRPA1GAACES2CES1 | |
| SCHEMBL9714887 | 0.82 | GSK3B (0.42) | POLBTRPA1GAACES2CES1 | |
| SCHEMBL11472847 | 0.76 | POLB (0.36) | POLBTRPA1GAAMAPK1TSHR | |
| SCHEMBL11068444 | 0.75 | PTGS2 (0.40) | POLBTRPA1MAPK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0323625-B1 | Process for preparing 3-[2-chloro-2(4-chlorophenyl)-vinyl]-2,2-dimethyl-cyclopropane carboxylic acid | BAYER AG (DE) | 1992-09-09 | — | — | EP | disclosed |
| US-4992577-A | Preparation of 3-vinyl-substituted 2,2-dimethylcyclopropane-1-carboxylic acids and esters and intermediates therefor | BAYER AKTIENGESELLSCHAFT (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4897505-A | Process for the preparation of 3-(2-chloro-2-(4-chloro-phenyl)-vinyl)-2,2-dimethylcyclopropanecarboxylic acid | BAYER AKTIENGESELLSCHAFT (DE) | 1990-01-30 | — | — | US | disclosed |
| EP-0323625-A2 | Process for preparing 3-[2-chloro-2(4-chlorophenyl)-vinyl]-2,2-dimethyl-cyclopropane carboxylic acid | BAYER AG (DE) | 1989-07-12 | — | — | EP | disclosed |
| EP-0095047-B1 | PROCESS FOR THE PREPARATION OF 3-VINYL-SUBSTITUTED 2,2-DIMETHYL-CYCLOPROPANE-1-CARBOXYLIC ACIDS OR THEIR ESTERS, AND INTERMEDIATE PRODUCTS THEREFOR | BAYER AG (DE) | 1985-11-27 | — | — | EP | disclosed |
| EP-0095047-A1 | Process for the preparation of 3-vinyl-substituted 2,2-dimethyl-cyclopropane-1-carboxylic acids or their esters, and intermediate products therefor | BAYER AG (DE) | 1983-11-30 | — | — | EP | disclosed |