SCHEMBL9715004

SCHEMBL9715004

C=C(C)C(=O)OCC[Si](C)(O)O[Si](C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.46
TSHR P16473 3/20 0.44
ALDH1A1 P00352 2/20 0.40
POLB P06746 1/20 0.38
APEX1 P27695 1/20 0.38
HTT P42858 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9715028 0.90 TSHR (0.50) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL9715006 0.86 THRB (0.46) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL396766 0.84 THRB (0.47) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL9303996 0.84 THRB (0.47) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL396934 0.84 THRB (0.47) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL17750831 0.82 TSHR (0.53) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL396535 0.81 TSHR (0.42) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL10595373 0.81 THRB (0.42) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL25329219 0.81 THRB (0.52) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL12660503 0.79 THRB (0.50) THRBTSHRALDH1A1POLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP claimed
EP-0242080-A2 Copolymer compositions PARAGON OPTICAL INC (US) 1987-10-21 EP claimed
US-4661573-A INTRAOCULAR AND CONTACT LENSES; COPOLYMER OF PERFLUROALKYL ACRYLATE, ACRYLOXYALKYLPOLYSILOXANE, ACRYLOXYALKYLSILANOL, POLYACRYLOXYALKYLPOLYSILOXANE PARAGON OPTICAL INC. (US) 1987-04-28 US claimed
EP-0242080-B1 COPOLYMER COMPOSITIONS PARAGON OPTICAL INC (US) 1992-12-16 EP disclosed
US-5002979-A Hyydrogenorganosilicon monomer, organosilicon, fluoroorgano monomer, a hydrophobic monomer and a crosslinking agent BAUSCH & LOMB INCORPORATED (US) 1991-03-26 US disclosed
EP-0215817-B1 CONTINUOUS-WEAR LENSES Bausch & Lomb Incorporated (US) 1991-03-13 EP disclosed
EP-0192683-B1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE PARAGON OPTICAL INC (US) 1989-12-20 EP disclosed
US-4829137-A Continuous-wear highly oxygen permeable contact lenses BAUSCH & LOMB INCORPORATED (US) 1989-05-09 US disclosed
EP-0184924-B1 LENS COMPOSITION, ARTICLES AND METHOD OF MANUFACTURE PARAGON OPTICAL INC (US) 1988-11-30 EP disclosed
US-4769431-A Polyacryloxyalkylsilanol lens composition, articles and method of manufacture PARAGON OPTICAL INC. (US) 1988-09-06 US disclosed
EP-0242080-A2 Copolymer compositions PARAGON OPTICAL INC (US) 1987-10-21 EP disclosed
EP-0215817-A1 CONTINUOUS-WEAR LENSES. BAUSCH & LOMB (US) 1987-04-01 EP disclosed
EP-0192683-A4 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE. PARAGON OPTICAL INC (US) 1987-02-19 EP disclosed
EP-0209597-A1 EXTENDED-WEAR LENSES Bausch & Lomb Incorporated (US) 1987-01-28 EP disclosed
EP-0192683-A1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE. PARAGON OPTICAL INC (US) 1986-09-03 EP disclosed
WO-1986004341-A1 CONTINUOUS-WEAR LENSES BAUSCH AND LOMB INCORPORATED (US) 1986-07-31 WO disclosed
WO-1986004343-A1 EXTENDED-WEAR LENSES BAUSCH AND LOMB INCORPORATED (US) 1986-07-31 WO disclosed
US-4582884-A Lens composition, article and method of manufacture PARAGON OPTICAL, INC. (US) 1986-04-15 US disclosed
WO-1986001518-A1 LENS COMPOSITION, ARTICLE AND METHOD OF MANUFACTURE PARAGON OPTICAL, INC. (US) 1986-03-13 WO disclosed
US-4419505-A HYDROXYSILYLALKYL (METH)ACRYLATE COPOLYMER PARAGON OPTICAL, INC. (US) 1983-12-06 US disclosed