Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Butyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.92 |
| ▸ | ATM | Q13315 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyl Fumarate SCHEMBL29604195 | 0.96 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL27358297 | 0.96 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Maleic Acid SCHEMBL27358295 | 0.96 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL124163 | 0.96 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL43164 | 0.96 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Maleic Acid SCHEMBL28199237 | 0.96 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL4376900 | 0.96 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL43165 | 0.96 | HCAR2 (1.00) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL6905849 | 0.94 | HCAR2 (0.96) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Butyl Fumarate SCHEMBL1223794 | 0.94 | HCAR2 (0.96) | HCAR2ATMMAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948959-B1 | Nonionically derivatized starches and their use in low voc, polyacrylic acid-containing hair fixative compositions | NAT STARCH CHEM INVEST (US) | 2008-12-31 | — | — | EP | claimed |
| EP-0948960-B1 | Nonionically derivatized starches and their use in non-aerosol, low voc hair fixative compositions | NAT STARCH CHEM INVEST (US) | 2008-12-31 | — | — | EP | claimed |
| EP-0948958-B1 | Non-ionically derivatized starches and their use in aerosol hair fixative compositions | NAT STARCH CHEM INVEST (US) | 2006-06-21 | — | — | EP | claimed |
| US-6562325-B2 | Hair setting gel | NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION | 2003-05-13 | — | — | US | claimed |
| US-6413505-B1 | SLURRY OF STARCH AND POLYMER; FILM FORMING | NATIONA L STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6344183-B2 | ALSO CONTAINING PROPELLANT, SOLVENT, AND WATER; LOW VISCOSITY; GOOD SPRAY CHARACTERISTICS; CLEAR, NON-TACKY FILM; GOOD STIFFNESS; HUMIDITY RESISTANCE | NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION | 2002-02-05 | — | — | US | claimed |
| US-20010018046-A1 | USE OF STABILIZED STARCHES IN LOW VOC, POLYACRYLIC ACID-CONTAINING HAIR COSMETIC COMPOSITIONS | AKZO NOBEL N.V. (NL) | 2001-08-30 | — | — | US | claimed |
| US-20010007655-A1 | AEROSOL HAIR COSMETIC COMPOSITIONS CONTAINING NON-IONICALLY DERIVATIZED STARCHES | AKZO NOBEL N.V. (NL) | 2001-07-12 | — | — | US | claimed |
| EP-0948960-A2 | Nonionically derivatized starches and their use in non-aerosol, low voc hair fixative compositions | National Starch and Chemical Investment Holding Corporation (US) | 1999-10-13 | — | — | EP | claimed |
| EP-0948959-A2 | Nonionically derivatized starches and their use in low voc, polyacrylic acid-containing hair fixative compositions | National Starch and Chemical Investment Holding Corporation (US) | 1999-10-13 | — | — | EP | claimed |
| EP-0948958-A2 | Non-ionically derivatized starches and their use in aerosol hair fixative compositions | National Starch and Chemical Investment Holding Corporation (US) | 1999-10-13 | — | — | EP | claimed |
| EP-0635257-B1 | Low VOC hair sprays with improved spray characteristics | NAT STARCH CHEM INVEST (US) | 1997-10-01 | — | — | EP | claimed |
| EP-0635257-A1 | Low VOC hair sprays with improved spray characteristics | National Starch and Chemical Investment Holding Corporation (US) | 1995-01-25 | — | — | EP | claimed |
| US-20240158557-A1 | MANUFACTURED POLYMERS HAVING ALTERED OLIGOSACCHARIDE OR POLYSACCHARIDE FUNCTIONALITY OR NARROWED OLIGOSACCHARIDE DISTRIBUTION, PROCESSES FOR PREPARING THEM, COMPOSITIONS CONTAINING THEM, AND METHODS OF USING THEM | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2024-05-16 | — | — | US | disclosed |
| EP-4341317-A1 | MANUFACTURED POLYMERS HAVING ALTERED OLIGOSACCHARIDE OR POLYSACCHARIDE FUNCTIONALITY OR NARROWED OLIGOSACCHARIDE DISTRIBUTION, PROCESSES FOR PREPARING THEM, COMPOSITIONS CONTAINING THEM, AND METHODS OF USING THEM | Nouryon Chemicals International B.V. (NL) | 2024-03-27 | — | — | EP | disclosed |
| CN-117730109-A | Artificial polymers with altered oligosaccharide or polysaccharide functionality or narrow oligosaccharide distribution, methods of making the same, compositions comprising the same, and methods of use thereof | 诺力昂化学品国际有限公司 | 2024-03-19 | — | — | CN | disclosed |
| US-4567035-A | Low molecular weight hair spray | GAF CORPORATION (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0135983-A2 | Low molucular weight hair spray resin | GAF CORPORATION (US) | 1985-04-03 | — | — | EP | disclosed |
| US-4155892-A | Polyurethane thickeners for aqueous compositions | ROHM AND HAAS COMPANY (US) | 1979-05-22 | — | — | US | disclosed |
| US-4079028-A | Polyurethane thickeners in latex compositions | ROHM AND HAAS COMPANY (US) | 1978-03-14 | — | — | US | disclosed |