Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9716625 | 0.92 | KDM4E (0.44) | AGTR1KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL8830080 | 0.83 | HSD17B10 (0.55) | KDM4EALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL341645 | 0.79 | KDM4E (0.71) | AGTR1KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL29620333 | 0.79 | KDM4E (0.71) | AGTR1KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL4415534 | 0.78 | AGTR1 (0.49) | AGTR1KDM4ERAB9AALDH1A1HPGD | |
| Methane SCHEMBL2342916 | 0.78 | KDM4E (0.69) | AGTR1KDM4ERAB9AALDH1A1HPGD | |
| Water SCHEMBL7614858 | 0.78 | KDM4E (0.69) | AGTR1KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL5692314 | 0.76 | PARP1 (0.51) | AGTR1KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL5707628 | 0.76 | POLB (0.56) | AGTR1KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL1499127 | 0.76 | AGTR1 (0.60) | AGTR1KDM4ERAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | claimed |
| EP-0178911-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1992-01-22 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0178911-A2 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1986-04-23 | — | — | EP | disclosed |