⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459030 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL10808909 | 0.98 | CHRNB2 (0.49) | — | |
| SCHEMBL9251598 | 0.87 | CHRNB2 (0.40) | — | |
| SCHEMBL6077803 | 0.87 | CHRNB2 (0.40) | — | |
| SCHEMBL27482791 | 0.84 | CHRNB2 (0.40) | — | |
| SCHEMBL3382673 | 0.80 | CHRNB2 (0.38) | — | |
| SCHEMBL21642939 | 0.80 | SLC6A12 (0.39) | — | |
| SCHEMBL19270289 | 0.80 | — | — | |
| SCHEMBL10167942 | 0.80 | — | — | |
| SCHEMBL1479146 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105593212-B | Phenyl-dihydrogen pyridine derivative as aldosterone synthase inhibitors | 豪夫迈·罗氏有限公司 | 2019-06-04 | — | — | CN | disclosed |
| EP-3057940-A1 | PHENYL-DIHYDROPYRIDINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE | F.HOFFMANN-LA ROCHE AG (CH) | 2016-08-24 | — | — | EP | disclosed |
| CN-105531263-A | Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthase | HOFFMANN LA ROCHE | 2016-04-27 | — | — | CN | disclosed |
| WO-2015055602-A1 | PHENYL-DIHYDROPYRIDINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-23 | — | — | WO | disclosed |
| EP-2298766-B1 | Pharmaceutical formulations comrpising a substituted pyridine derivative | LUNDBECK & CO AS H (DK) | 2013-09-18 | — | — | EP | disclosed |
| US-8299075-B2 | Substituted thiomorpholine derivatives | H. LUNDBECK A/S (DK) | 2012-10-30 | — | — | US | disclosed |
| US-8299071-B2 | Substituted pyridine derivatives | H. LUNDBECK A/S (DK) | 2012-10-30 | — | — | US | disclosed |
| US-20110294787-A1 | SUBSTITUTED THIOMORPHOLINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2011-12-01 | — | — | US | disclosed |
| US-8012962-B2 | Substituted thiomorpholine derivatives | H. LUNDBECK A/S (DK) | 2011-09-06 | — | — | US | disclosed |
| EP-2298766-A1 | Substituted pyridine derivatives | H. Lundbeck A/S (DK) | 2011-03-23 | — | — | EP | disclosed |
| EP-1947093-A1 | Substituted morpholine and thiomorpholine derivatives | H. Lundbeck A/S (DK) | 2008-07-23 | — | — | EP | disclosed |
| EP-1727809-B1 | SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2008-06-11 | — | — | EP | disclosed |
| CN-101133053-A | Substituted pyridine derivatives | LUNDBECK & CO AS H (DK) | 2008-02-27 | — | — | CN | disclosed |
| EP-1861394-A1 | SUBSTITUTED PYRIDINE DERIVATIVES | H.Lundbeck A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| CN-1930138-A | Substituted morpholine and thiomorpholine derivatives | LUNDBECK & CO AS H (DK) | 2007-03-14 | — | — | CN | disclosed |
| EP-1727809-A1 | SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES | H.Lundbeck A/S (DK) | 2006-12-06 | — | — | EP | disclosed |
| WO-2006092143-A1 | SUBSTITUTED PYRIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-09-08 | — | — | WO | disclosed |
| US-20060167248-A1 | Substituted morpholine and thiomorpholine derivatives | H. LUNDBECK A/S (DK) | 2006-07-27 | — | — | US | disclosed |
| WO-2005087754-A1 | SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2005-09-22 | — | — | WO | disclosed |
| US-6448051-B1 | USING A MORE EASILY AVAILABLE MICROBIAL WHOLE CELL ENZYME OF TRICHOSPORON | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2002-09-10 | — | — | US | disclosed |