Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9756796 | 1.00 | LMNA (0.59) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL9017128 | 1.00 | LMNA (0.59) | LMNABLMPTPN1MEN1CYP3A4 | |
| Water SCHEMBL15312410 | 0.98 | LMNA (0.56) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL10535505 | 0.91 | LMNA (0.59) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL10535502 | 0.91 | LMNA (0.59) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL11455553 | 0.83 | LMNA (0.62) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL11463913 | 0.83 | LMNA (0.62) | LMNABLMPTPN1MEN1CYP3A4 | |
| SCHEMBL669828 | 0.79 | — | — | |
| SCHEMBL336892 | 0.79 | — | — | |
| SCHEMBL20928 | 0.79 | LMNA (0.93) | LMNABLMPTPN1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153344-A | Vitamin E intermediates and a process for their manufacture and conversion into vitamin E | HOFFMAN-LA ROCHE INC. (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0269009-B1 | METHOD FOR THE PRODUCTION OF CARBINOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1991-07-31 | — | — | EP | disclosed |
| US-5034546-A | Novel vitamin E intermediates and a process for their manufacture and conversion into vitamin E | HOFFMANN-LA ROCHE INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4851585-A | Vitamin E intermediates | HOFFMANN-LA ROCHE INC. (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0269009-A2 | Method for the production of carbinol derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-06-01 | — | — | EP | disclosed |