SCHEMBL9717174

SCHEMBL9717174

COc1cc(NN)ccc1-c1ccc(NN)cc1OC

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 8/20 0.41
ALDH1A1 P00352 3/20 0.38
HTT P42858 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
GAA P10253 2/20 0.38
PLAU P00749 2/20 0.38
MAPK1 P28482 1/20 0.38
GFER P55789 1/20 0.38
PLAT P00750 1/20 0.38
NPC1 O15118 1/20 0.38
TP53 P04637 1/20 0.38
RAB9A P51151 1/20 0.38
MET P08581 1/20 0.37
CYP1A1 P04798 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2E1 P05181 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C8 P10632 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2A6 P11509 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9717163 0.88 PLAU (0.46) CYP17A1ALDH1A1PLAUPLATCYP1A1
SCHEMBL5361380 0.84 MAPT (0.50) ALDH1A1HTTSMN1; SMN2GAANPC1
SCHEMBL15476219 0.83 GRM4 (0.47) ALDH1A1SMN1; SMN2LMNAMAPT
SCHEMBL31276213 0.83 GRM4 (0.47) ALDH1A1SMN1; SMN2LMNAMAPT
Bromide SCHEMBL20984421 0.83 MAPT (0.49) ALDH1A1HTTSMN1; SMN2GAANPC1
Hydrochloric Acid SCHEMBL7408286 0.83 MAPT (0.49) ALDH1A1HTTSMN1; SMN2GAANPC1
Hydrochloric Acid SCHEMBL8202141 0.82 GRM4 (0.46) ALDH1A1SMN1; SMN2LMNAMAPT
SCHEMBL10564196 0.81 GRM4 (0.45) ALDH1A1HTTSMN1; SMN2GAAMAPK1
SCHEMBL8211026 0.81 ALDH1A1 (0.57) ALDH1A1HTTGAANPC1CYP3A4
SCHEMBL4133738 0.79 NPC1 (0.48) ALDH1A1GAANPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5091466-A Insolubilization of soluble pre-imidized polyimides by polyhydrazine compounds GENERAL ELECTRIC COMPANY (US) 1992-02-25 US disclosed