Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.48 |
| ▸ | PGR | P06401 | 7/20 | 0.48 |
| ▸ | AR | P10275 | 6/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9717248 | 1.00 | LMNA (0.54) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL24622441 | 0.84 | HIF1A (0.61) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL6523590 | 0.84 | HIF1A (0.61) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL2300385 | 0.84 | HIF1A (0.61) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL29043217 | 0.83 | LMNA (0.69) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL9521229 | 0.83 | LMNA (0.69) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL9521233 | 0.83 | LMNA (0.69) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL19762243 | 0.83 | LMNA (0.69) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL19931499 | 0.82 | LMNA (0.56) | LMNASMN1; SMN2HIF1APGRAR | |
| SCHEMBL11321836 | 0.79 | HIF1A (0.49) | LMNASMN1; SMN2HIF1APGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278319-B1 | 9,11-EPOXY-21-HYDROXYPREGNANE DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-10-07 | — | — | EP | disclosed |
| EP-0308412-B1 | 16$g(a)-METHYLATION PROCESS | THE UPJOHN COMPANY (US) | 1992-03-18 | — | — | EP | disclosed |
| US-4990612-A | 16α-methylation process | THE UPJOHN COMPANY (US) | 1991-02-05 | — | — | US | disclosed |
| EP-0165037-B1 | 16 ALPHA-METHYL STEROIDS AND THEIR PREPARATION | THE UPJOHN COMPANY (US) | 1990-09-19 | — | — | EP | disclosed |
| US-4929395-A | 16α-methylation process | THE UPJOHN COMPANY (US) | 1990-05-29 | — | — | US | disclosed |
| US-4891426-A | EPOXIDATION WITH PERACID | THE UPJOHN COMPANY (US) | 1990-01-02 | — | — | US | disclosed |
| US-4704455-A | 16α-methylatedΔ17(20)-corticoids | THE UPJOHN COMPANY (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0165037-A2 | 16 alpha-methyl steroids and their preparation | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |