SCHEMBL2300385

SCHEMBL2300385

CC(=O)OCC(=O)C1=CC[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 8/20 0.61
PGR P06401 8/20 0.61
AR P10275 7/20 0.61
NR3C1 P04150 6/20 0.61
CYP3A4 P08684 5/20 0.61
SMN1; SMN2 Q16637 3/20 0.61
ALDH1A1 P00352 3/20 0.61
CYP1A2 P05177 1/20 0.61
LMNA P02545 5/20 0.59
MEN1 O00255 1/20 0.58
KMT2A Q03164 1/20 0.58
NPSR1 Q6W5P4 1/20 0.56
NR1I2 O75469 2/20 0.52
HTR2B P41595 1/20 0.52
MAPT P10636 2/20 0.51
ABCB11 O95342 1/20 0.51
RAB9A P51151 1/20 0.51
ADORA3 P0DMS8 2/20 0.48
CHRM1 P11229 1/20 0.48
ADRA1A P35348 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24622441 1.00 HIF1A (0.61) HIF1APGRARNR3C1CYP3A4
SCHEMBL6523590 1.00 HIF1A (0.61) HIF1APGRARNR3C1CYP3A4
SCHEMBL12528263 0.91 LMNA (0.59) HIF1APGRARNR3C1CYP3A4
SCHEMBL2297384 0.88 PGR (0.61) HIF1APGRARNR3C1CYP3A4
SCHEMBL6522031 0.88 PGR (0.61) HIF1APGRARNR3C1CYP3A4
SCHEMBL2296903 0.88 PGR (0.56) HIF1APGRARNR3C1CYP3A4
SCHEMBL14680126 0.88 PGR (0.56) HIF1APGRARNR3C1CYP3A4
SCHEMBL12524081 0.88 PGR (0.61) HIF1APGRARNR3C1CYP3A4
SCHEMBL18971904 0.88 PGR (0.61) HIF1APGRARNR3C1CYP3A4
SCHEMBL16523019 0.87 PGR (0.56) HIF1APGRARNR3C1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4271387-A1 NOVEL STEROID PAYLOADS, STEROID LINKERS, ADCS CONTAINING AND USE THEREOF Immunext, Inc. (US) 2023-11-08 EP disclosed
US-20230310634-A1 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF IMMUNEXT INC (US) 2023-10-05 US disclosed
US-20230310634-A1 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF IMMUNEXT INC (US) 2023-10-05 US disclosed
WO-2022150637-A1 NOVEL STEROID PAYLOADS, STEROID LINKERS, ADCs CONTAINING AND USE THEREOF IMMUNEXT, INC. (US) 2022-07-14 WO disclosed
WO-2022150637-A1 NOVEL STEROID PAYLOADS, STEROID LINKERS, ADCs CONTAINING AND USE THEREOF IMMUNEXT, INC. (US) 2022-07-14 WO disclosed
EP-2475676-B1 Pregnane derivatives condensed in the 16,17 position with an N-substituted isoxazolidine ring as anti-inflammatory agents CHIESI FARM SPA (IT) 2020-05-27 EP disclosed
US-10280193-B2 Isoxazolidine derivatives CHIESI FARMACEUTICI S.P.A. (IT) 2019-05-07 US disclosed
US-10280193-B2 Isoxazolidine derivatives CHIESI FARMACEUTICI S.P.A. (IT) 2019-05-07 US disclosed
US-20180066010-A1 ISOXAZOLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2018-03-08 US disclosed
US-20180066010-A1 ISOXAZOLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2018-03-08 US disclosed
US-20120238531-A1 ISOXAZOLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2012-09-20 US disclosed
US-20120234316-A1 ISOXAZOLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2012-09-20 US disclosed
US-20110201580-A1 PYRROLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2011-08-18 US disclosed
US-20110201580-A1 PYRROLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2011-08-18 US disclosed
US-20110201580-A1 PYRROLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2011-08-18 US disclosed
WO-2011095535-A2 PYRROLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2011-08-11 WO disclosed
WO-2011029547-A2 PREGNANE DERIVATIVES CONDENSED IN THE 16, 17 POSITION WITH AN N-SUBSTITUTED ISOXAZOLIDINE RING AS ANTI-INFLAMMATORY AGENTS CHIESI FARMACEUTICI S.P.A. (IT) 2011-03-17 WO disclosed
US-20110065678-A1 ISOXAZOLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2011-03-17 US disclosed
US-20110065678-A1 ISOXAZOLIDINE DERIVATIVES CHIESI FARMACEUTICI S.P.A. (IT) 2011-03-17 US disclosed
US-4232013-A ANTIINFLAMMATORY AGENTS, RHEUMATISM LARK S.P.A. (IT) 1980-11-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120234316-A1 ISOXAZOLIDINE DERIVATIVES IL5, TSLP, SERPINA6 HIF1A 646/4885PGR 2154/4885AR 1427/4885
US-20110065678-A1 ISOXAZOLIDINE DERIVATIVES NR3C2, NR3C1, MC2R HIF1A 2445/4885PGR 1856/4885AR 731/4885
US-20120238531-A1 ISOXAZOLIDINE DERIVATIVES IL5, TSLP, LTB4R2 HIF1A 815/4885PGR 2176/4885AR 1237/4885
US-20180066010-A1 ISOXAZOLIDINE DERIVATIVES IL5, TSLP, SERPINA6 HIF1A 646/4885PGR 2154/4885AR 1427/4885
US-10280193-B2 Isoxazolidine derivatives IL5, TSLP, SERPINA6 HIF1A 646/4885PGR 2154/4885AR 1427/4885
US-20230310634-A1 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF CD47, CLTA, FCGR2A HIF1A 2042/4885PGR 2891/4885AR 1117/4885
US-20110201580-A1 PYRROLIDINE DERIVATIVES IL5, TSLP, NR3C1 HIF1A 2209/4885PGR 215/4885AR 1292/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.