Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8384266 | 0.86 | KDM4E (0.53) | KDM4EMMP2MMP8MMP12ADAMTS5 | |
| SCHEMBL4171208 | 0.84 | ESR1 (0.59) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27461036 | 0.84 | CYP3A4 (0.50) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5948337 | 0.83 | CYP3A4 (0.67) | MMP8ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL25344198 | 0.83 | MMP2 (0.51) | KDM4EMMP2MMP8MMP12ADAMTS5 | |
| SCHEMBL14185300 | 0.83 | KDM4E (0.62) | KDM4EMMP2MMP8MMP12ADAMTS5 | |
| SCHEMBL7906601 | 0.83 | KDM4E (0.50) | KDM4EMMP2MMP8MMP12ADAMTS5 | |
| SCHEMBL16041240 | 0.82 | ALDH1A1 (0.49) | ALDH1A1CYP3A4CYP2C9CYP2C19HPGD | |
| SCHEMBL1998840 | 0.82 | CYP3A4 (0.49) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28794058 | 0.82 | CYP2C9 (0.49) | KDM4EALDH1A1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153327-A | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5100889-A | Thromboxane A2 receptor antagonists, thromboxane synthetase inhibitor | E. R. SQUIBB & SONS, INC. (US) | 1992-03-31 | — | — | US | disclosed |