SCHEMBL9718607

SCHEMBL9718607

CC(O)(c1ccccc1)c1noc(C2CN3CCC2CC3)n1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.48
LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9718595 0.88 LMNA (0.49) LMNA
SCHEMBL9718581 0.85 LMNA (0.44) LMNA
SCHEMBL9718606 0.83 LMNA (0.44) CHRM2LMNA
SCHEMBL10518459 0.82 CHRM2 (0.52) CHRM2LMNA
SCHEMBL9718619 0.82 LMNA (0.43) LMNA
SCHEMBL9718605 0.82 LMNA (0.41) LMNA
SCHEMBL9718624 0.81 LMNA (0.42) LMNA
SCHEMBL24434493 0.80 CHRM2 (0.56) CHRM2
SCHEMBL10518670 0.77 GAA (0.40)
SCHEMBL9718617 0.74 KCNH2 (0.65)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0323864-A2 Lipophilic oxadiazoles MERCK SHARP & DOHME LTD. (GB) 1989-07-12 EP claimed
US-5135935-A Anticholesterol agents MERCK & CO., INC. (US) 1992-08-04 US disclosed
EP-0323864-A2 Lipophilic oxadiazoles MERCK SHARP & DOHME LTD. (GB) 1989-07-12 EP disclosed