Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.45 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.45 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.45 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.45 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.45 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.45 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.45 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.45 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.44 |
| ▸ | SETD7 | Q8WTS6 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9718755 | 1.00 | SETD7 (0.51) | SETD7HRH1HTTCHRM2CHRM4 | |
| SCHEMBL9718787 | 0.94 | SETD7 (0.57) | SETD7HRH1HTTCHRM2CHRM4 | |
| SCHEMBL9718753 | 0.84 | SETD7 (0.57) | SETD7HRH1HTTCHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9718774 | 0.83 | SETD7 (0.56) | SETD7HRH1HTTCHRM2CHRM4 | |
| SCHEMBL9718730 | 0.82 | SETD7 (0.51) | SETD7HRH1CHRM2ADRA2ACHRM1 | |
| Hydrochloric Acid SCHEMBL9718822 | 0.78 | SETD7 (0.65) | SETD7HRH1HTTCHRM2CHRM4 | |
| SCHEMBL9718757 | 0.76 | KCNH2 (0.49) | SETD7HRH1ALDH1A1TP53TSHR | |
| SCHEMBL9718762 | 0.75 | SETD7 (0.61) | SETD7HRH1HTTCHRM2CHRM4 | |
| SCHEMBL4514999 | 0.75 | SETD7 (0.58) | SETD7HRH1HTTCHRM2CHRM4 | |
| SCHEMBL9034258 | 0.75 | SETD7 (0.60) | SETD7HRH1HTTCHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5095022-A | Antiallergens | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1992-03-10 | — | — | US | disclosed |
| EP-0406739-A2 | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1991-01-09 | — | — | EP | disclosed |