Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9718936 | 1.00 | LMNA (0.39) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9718943 | 1.00 | LMNA (0.39) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9717559 | 0.88 | LMNA (0.39) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9717566 | 0.88 | LMNA (0.39) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9717532 | 0.82 | FFAR4 (0.41) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9717519 | 0.82 | FFAR4 (0.41) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9717525 | 0.82 | FFAR4 (0.41) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9717590 | 0.81 | CYSLTR2 (0.40) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9717589 | 0.81 | CYSLTR2 (0.40) | LMNAFBP1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL9717583 | 0.81 | CYSLTR2 (0.40) | LMNAFBP1ALDH1A1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240256-B1 | COMPOUNDS USEFUL IN TREATING SICKLE CELL ANEMIA | MERCK & CO. INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| US-4751244-A | NITROALKENYL CARBOXYLIC ACIDS | MERCK & CO., INC. (US) | 1988-06-14 | — | — | US | disclosed |
| EP-0240256-A2 | Compounds useful in treating sickle cell anemia | MERCK & CO. INC. (US) | 1987-10-07 | — | — | EP | disclosed |