Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 12/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 11/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 9/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 9/20 | 0.35 |
| ▸ | PTGFR | P43088 | 3/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.34 |
| ▸ | PTGIR | P43119 | 2/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9718305 | 0.78 | TBXA2R (0.36) | TBXA2R | |
| SCHEMBL9718211 | 0.74 | PTGER3 (0.44) | PTGER3PTGER2TBXA2RPTGDRPTGER4 | |
| SCHEMBL28566740 | 0.67 | BACE1 (0.69) | PTGER3PTGER2TBXA2RPTGDRBACE1 | |
| SCHEMBL9718143 | 0.66 | TBXA2R (0.31) | TBXA2R | |
| SCHEMBL9718260 | 0.65 | TBXA2R (0.38) | TBXA2R | |
| SCHEMBL27706278 | 0.65 | BACE1 (0.42) | BACE1TBXAS1KDM4E | |
| SCHEMBL1774349 | 0.64 | PTGER3 (0.52) | PTGER3PTGER2TBXA2RPTGDRPTGER4 | |
| SCHEMBL29045408 | 0.63 | PTGER3 (0.52) | PTGER3PTGER2TBXA2RPTGDRPTGER4 | |
| SCHEMBL8573281 | 0.62 | PTGER3 (0.57) | PTGER3PTGER2TBXA2RPTGDRPTGER4 | |
| SCHEMBL1716473 | 0.62 | PTGER3 (0.56) | PTGER3PTGER2TBXA2RPTGDRPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153327-A | 7-Oxabicycloheptyl substituted heterocyclic amide or ester prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease | E. R. SQUIBB & SONS, INC. (US) | 1992-10-06 | — | — | US | disclosed |